PI3K isoform selective inhibitors
作者： Congxin Liang , Zhi-gang Li
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摘要: 2-Morpholin-4-yl-9H-purine and 5-Morpholin-4-yl-3H-[ 1,2,3]triazolo[4,5-d] pyrimidine derivatives, especially those substituted by 6-heteroaryl, are unexpected PI3 kinase isoform selective inhibitors with good drug properties useful in treating disorders related to abnormal PI3K activities such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine neurological disorders.
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