Microcystic adenomas (serous cystadenomas) of pancreas. A clinicopathologic investigation of eight cases with immunohistochemical and ultrastructural studies.

摘要: Microcystic adenomas are rare tumors, which have only recently been distinguished from other cystic pancreatic lesions. This study details eight cases diagnosed at the Cleveland Clinic. Seven occurred in females. The mean age diagnosis was 66 years. Abdominal or epigastric pain most common symptom. A history of extrapancreatic tumors frequent, and one patient had a concomitant renal carcinoma with adrenal cysts. were multicystic, ranging size 2 to 14 cm. Cuboidal epithelial cells vacuolated clear cytoplasm containing abundant glycogen lined intervening stromal septa collagenous hypocellular. exhibited strongly positive immunostaining for cytokeratins AE1 AE3, but did not stain CEA Uro-2,3, 4. Ultrastructurally, rested on well-formed basal lamina delicate subepithelial capillary network. They blunted apical microvilli contained glycogen, few lipid droplets, occasional secretory granules. Five resected, three diagnostic biopsy. There no metastases, died postoperative complications following local excision. Elderly high-risk patients may benefit more biopsy alone than attempts total surgical resection these benign tumors.