The long-term maintenance of cytotoxic T cell memory does not require persistence of antigen.

摘要: I have used the transfer of primed lymphocytes into syngeneic irradiated recipients to investigate whether persistence antigen is required in long-term maintenance cytolytic T cell memory influenza virus. Animals were immunized with virus (A/WSN) and 17 wk later as either donors for cells or lethally recipients. Naive age-matched mice served controls. At intervals 4, 8, 16, 25 after transfer, experimental control groups a heterologous (A/JAP) splenocytes tested lytic activity 3 6 d immunization. Lytic infection (a property exclusive cytotoxic response) (Effros, R. B., J. Bennink, P. C. Doherty. 1978. Cell. Immunol. 36:345.; Hill, A. V. Blanden, Parrish, Mullbacher. 1992. Cell Biol. 70:259), was only observed by naive reconstituted cells. No day responses when transferred unprimed These observations demonstrate that long lived absence antigen.