The Ability to Promote Efflux Via ABCA1 Determines the Capacity of Serum Specimens With Similar High-Density Lipoprotein Cholesterol to Remove Cholesterol From Macrophages
作者： Margarita de la Llera-Moya , Denise Drazul-Schrader , Bela F. Asztalos , Marina Cuchel , Daniel J. Rader
DOI: 10.1161/ATVBAHA.109.199158
关键词:
摘要: Objective— We measured efflux from macrophages to apolipoprotein B-depleted serum 263 specimens and found instances in which having similar high-density lipoprotein cholesterol (HDL-C) differed their capacity. Thus, we wanted elucidate why capacity could be independent of total HDL-C or A-I (apoA-I). Methods Results— To understand sera with apoA-I differ capacity, assessed ability promote via the pathways expressed cAMP-treated J774 macrophages. Briefly, were preincubated probucol block ABCA1, BLT-1 SR-BI, both inhibitors measure residual efflux. ABCG1 was transfected BHK-1 cells. used values at 25th 75th percentiles. Specimens each group classified as high low based on being above below average. f...
sci-hub.se 参考文章(34)
George H Rothblat, Marina Cuchel, Daniel J Rader, Megan L Wolfe, Margarita de la Llera-Moya, Julie A Phillips, Abstract 1695: The Cholesterol Efflux Capacity of Serum Predicts Carotid Intimal-Medial Thickness Independently of HDL-C and Apo A-I Levels Circulation. ,vol. 118, ,(2008)
S J Smith, G R Cooper, G L Myers, E J Sampson, Biological Variability in Concentrations of Serum Lipids: Sources of Variation Among Results From Published Studies and Composite Predicted Values Clinical Chemistry. ,vol. 39, pp. 1012- 1022 ,(1993) , 10.1093/CLINCHEM/39.6.1012
Daniel J. Rader, Molecular regulation of HDL metabolism and function: implications for novel therapies Journal of Clinical Investigation. ,vol. 116, pp. 3090- 3100 ,(2006) , 10.1172/JCI30163
Cesare R. Sirtori, Laura Calabresi, Guido Franceschini, Damiano Baldassarre, Mauro Amato, Jan Johansson, Massimo Salvetti, Cristina Monteduro, Roberto Zulli, Maria L. Muiesan, Enrico Agabiti-Rosei, Cardiovascular Status of Carriers of the Apolipoprotein A-IMilano Mutant The Limone sul Garda Study Circulation. ,vol. 103, pp. 1949- 1954 ,(2001) , 10.1161/01.CIR.103.15.1949
Fiona C. McGillicuddy, Margarita de la Llera Moya, Christine C. Hinkle, Michelle R. Joshi, Elise H. Chiquoine, Jeffrey T. Billheimer, George H. Rothblat, Muredach P. Reilly, Inflammation Impairs Reverse Cholesterol Transport In Vivo Circulation. ,vol. 119, pp. 1135- 1145 ,(2009) , 10.1161/CIRCULATIONAHA.108.810721
Alan R. Tall, Laurent Yvan-Charvet, Naoki Terasaka, Tamara Pagler, Nan Wang, HDL, ABC transporters, and cholesterol efflux: implications for the treatment of atherosclerosis. Cell Metabolism. ,vol. 7, pp. 365- 375 ,(2008) , 10.1016/J.CMET.2008.03.001
Ashley M. Vaughan, John F. Oram, ABCG1 Redistributes Cell Cholesterol to Domains Removable by High Density Lipoprotein but Not by Lipid-depleted Apolipoproteins Journal of Biological Chemistry. ,vol. 280, pp. 30150- 30157 ,(2005) , 10.1074/JBC.M505368200
Agnes E. La Ville, Rosa Sola, Jordi Balanya, Peter R. Turner, Lluis Masana, In vitro oxidised HDL is recognised by the scavenger receptor of macrophages: implications for its protective role in vivo Atherosclerosis. ,vol. 105, pp. 179- 189 ,(1994) , 10.1016/0021-9150(94)90048-5
Huali Zhou, Kathryn C. B. Tan, Sammy W. M. Shiu, Ying Wong, Cellular cholesterol efflux to serum is impaired in diabetic nephropathy Diabetes-metabolism Research and Reviews. ,vol. 24, pp. 617- 623 ,(2008) , 10.1002/DMRR.895
Elda Favari, Miriam Lee, Laura Calabresi, Guido Franceschini, Francesca Zimetti, Franco Bernini, Petri T. Kovanen, Depletion of Pre-β-high Density Lipoprotein by Human Chymase Impairs ATP-binding Cassette Transporter A1- but Not Scavenger Receptor Class B Type I-mediated Lipid Efflux to High Density Lipoprotein Journal of Biological Chemistry. ,vol. 279, pp. 9930- 9936 ,(2004) , 10.1074/JBC.M312476200