Cyclin D1 gene amplification and overexpression are present in ductal carcinoma in situ of the breast
作者： Carla B. J. Vos , Natalja T. ter Haar , Johannes L. Peterse , Cees J. Cornelisse , Marc J. van de Vijver
DOI: 10.1002/(SICI)1096-9896(199902)187:3<279::AID-PATH240>3.0.CO;2-C
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摘要: Cyclin D1 (CCND1) amplification is found in 10-15 per cent of invasive breast carcinomas, but it not well established whether this gene alteration also occurs the precursor carcinoma, ductal carcinoma situ (DCIS). By Southern blot analysis, cyclin was detected 10 (3/32) DCIS cases. In addition, 15 cases were analysed using bright field hybridization (BRISH), which 11 had already been by blotting. One additional case with BRISH. The use BRISH for detection shown to be a novel and reliable method on paraffin-embedded tissue sections. immunohistochemistry, 147 expression D1. overexpression 9 well-differentiated, 29 intermediately differentiated, 19 poorly differentiated DCIS. No statistically significant association between differentiation grade DCIS, although 90 that show are classified as differentiated. An oestrogen receptor positivity. all four amplification, 30 (8/27) without detectable amplification. It concluded an early event development protein present tumours seen predominantly histological type
sci-hub.se 参考文章(26)
V Eusebi, B Zafrani, J L Peterse, R Holland, D Faverly, R R Millis, M J van de Vijver, Ductal carcinoma in situ: a proposal for a new classification. Seminars in Diagnostic Pathology. ,vol. 11, pp. 167- 180 ,(1994)
Jan-Willem Vaandrager, Philip Kluin, Ed Schuuring, The t(11;14) (q13;q32) in multiple myeloma cell line KMS12 has its 11q13 breakpoint 330 kb centromeric from the cyclin D1 gene. Blood. ,vol. 89, pp. 349- 349 ,(1997) , 10.1182/BLOOD.V89.1.349.349_349_349
Godolphin W, Pauletti G, Press Mf, Slamon Dj, Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization. Oncogene. ,vol. 13, pp. 63- 72 ,(1996)
T. Odom-Maryon, P. E. Clarke, D. E. Quan, F. O'Malley, J. F. Simpson, Amplification of CCND1 and expression of its protein product, cyclin D1, in ductal carcinoma in situ of the breast. American Journal of Pathology. ,vol. 151, pp. 161- 168 ,(1997)
I T Young, Proof without prejudice: use of the Kolmogorov-Smirnov test for the analysis of histograms from flow systems and other sources.: Journal of Histochemistry and Cytochemistry. ,vol. 25, pp. 935- 941 ,(1977) , 10.1177/25.7.894009
Debra Weinstat-Saslow, Maria J. Merino, Richard E. Manrow, Julia A. Lawrence, Ray F. Bluth, Karl D. Wittenbel, Jean F. Simpson, David L. Page, Patricia S. Steeg, Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions Nature Medicine. ,vol. 1, pp. 1257- 1260 ,(1995) , 10.1038/NM1295-1257
Guoren Deng, Mei Yu, Ling-Chun Chen, Dan Moore, Wayne Kurisu, Anne Kallioniemi, Frederick M. Waldman, Colin Collins, Helene S. Smith, Amplifications of oncogene erbB-2 and chromosome 20q in breast cancer determined by differentially competitive polymerase chain reaction Breast Cancer Research and Treatment. ,vol. 40, pp. 271- 281 ,(1996) , 10.1007/BF01806816
J C Adams, Biotin amplification of biotin and horseradish peroxidase signals in histochemical stains. Journal of Histochemistry and Cytochemistry. ,vol. 40, pp. 1457- 1463 ,(1992) , 10.1177/40.10.1527370
S D Worsley, B A Jennings, K H Khalil, M Mole, A C Girling, Cyclin D1 amplification and expression in human breast carcinoma: correlation with histological prognostic markers and oestrogen receptor expression. Clinical molecular pathology. ,vol. 49, ,(1996) , 10.1136/MP.49.1.M46
Gordon Peters, Vera Fantl, Rosalind Smith, Sharon Brookes, Clive Dickson, Chromosome 11q13 markers and D-type cyclins in breast cancer Breast Cancer Research and Treatment. ,vol. 33, pp. 125- 135 ,(1995) , 10.1007/BF00682720