Cyclin D1 amplification and expression in human breast carcinoma: correlation with histological prognostic markers and oestrogen receptor expression.
作者： S D Worsley , B A Jennings , K H Khalil , M Mole , A C Girling
DOI: 10.1136/MP.49.1.M46
关键词:
摘要: Aims —To study the amplification of Cyclin D1 gene (CCND1) in human breast carcinoma; to relate this protein expression; these parameters recognised pathological prognostic factors, including oestrogen receptor (ER) status. Methods —DNA extracted from frozen sections tumours (n = 36) was used for Southern blotting. Probes CCND1, c- myc and immunoglobulin heavy chain locus (IgH) were hybridised tumour DNA. Immunocytochemical expression ER studied paraffin wax same tumours. Results —Amplification CCND1 observed 11% (four studied. Over 73% (30/41) There no correlation between histological markers either or expression. However, a weak association seen Conclusions —A disparity exists over D1, suggesting existence another mechanism raised No significant detected established markers.
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