N-acetyl-L-cysteine increases acute graft-versus-host disease and promotes T-cell-mediated immunity in vitro.
作者： Helen Karlsson , Silvia Nava , Mats Remberger , Zuzana Hassan , Moustapha Hassan
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摘要: N-acetyl-L-cysteine (NAC) is a thiol antioxidant that stimulates glutathione synthesis in cells. Several studies indicate NAC possesses immunomodulatory properties vitro, but both inhibitory and activating effects on immunity have been reported. We observed allogeneic stem cell transplantation (ASCT) patients who were randomized to receive 100 mg/kg/day (n=73) had an increased prevalence of grade II-V acute graft-versus-host disease (GvHD) compared did not (n=87), indicating has immunostimulatory effect vivo. When studying the T-cell-mediated we found moderate levels (0.4–3.2 mM) alloantigen-induced proliferation, expression activation markers CD25 CD71 T cells, production IFN-γ IL-10. In contrast, high concentrations (12.5–50 mM) suppressive, which may explain previously conflicting data. cause increase CD86, CD80, CD83 mature DCs at any concentration, whereas suppressed DC maturation. Furthermore, cells exposed suppressive primary stimulation highly responsive when re-stimulated absence NAC. To conclude, appears GvHD alloantigen-specific
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