Modification effects of GSTM1, GSTT1 and CYP2E1 polymorphisms on associations between raw salted food and incomplete intestinal metaplasia in a high‐risk area of stomach cancer

摘要: Incomplete intestinal metaplasia (IM) is a precursor of stomach cancer. To identify risk factors incomplete IM, 2-stage survey was carried out in 1995 among 1,485 residents Matzu, an area with highest mortality from cancer Taiwan. There were 312 study subjects including 174 men and 138 women sampled for the gastroendoscopic examination IM. Information on personal familial history cancer, cigarette smoking, alcohol consumption intake frequency various salted food items obtained by interview based structured questionnaire. Blood samples collected each participant. Four biopsies per subject taken all at to diagnose status IM pathologically. The Helicobacter pylori detected histomorphological or immunochemistry method, antibodies against H. serum enzyme-linked immunosorbent assay. Plasma level selenium determined atomic absorption spectrometry, plasma retinol, alpha-tocopherol, alpha-carotene, beta-carotene high performance liquid chromatography, genotypes glutathione S-transferase (GST) M1 T1 cytochrome P450 (CYP) 2E1 polymerase chain reaction. significant association between first-degree relatives found (odds ratio [OR] = 2.50; 95% confidence interval [CI] 1.15-5.43). no infection Alcohol drinkers >20 years had elevated compared non-drinkers (OR 3.34; CI 1.19-9.39). No associations levels selenium, alpha-carotene found. Salted meat, dehydrated vegetables raw seafood consumed ages