Global Transcriptome Analysis of Lactococcus garvieae Strains in Response to Temperature

摘要: Lactococcus garvieae is an important fish and opportunistic human pathogen. The genomic sequences of several L. strains have been recently published, opening the possibility global studies on biology this In study, a whole genome DNA microarray two was designed validated. This used to investigate effects growth temperature (18°C 37°C) transcriptome clinical that were isolated from (Lg8831) case septicemia (Lg21881). profiles evidenced strain-specific response temperature, which more evident at 18°C. Among most significant findings, Lg8831 found up-regulate 18°C genes encoding different cold-shock cold-induced proteins involved in efficient adaptive strain low-temperature conditions. Another relevant result description, for first time, respiratory metabolism garvieae, whose gene expression regulation temperature-dependent Lg21881. study provides new insights about how environmental factors such as can affect expression. These data could improve our understanding regulatory networks