作者: Hana Yu , Adetola B Adesida , Nadr M Jomha
DOI: 10.1186/S13287-015-0077-2
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摘要: The menisci are a pair of semilunar fibrocartilage structures that play an essential role in maintaining normal knee function. Injury to the can disrupt joint stability and lead debilitating results. Because natural meniscal healing is limited, efficient method repair necessary. Tissue engineering (TE) combines principles life sciences restore unique architecture native meniscus. Mesenchymal stem cells (MSCs) have been investigated for their therapeutic potential both vitro vivo. This comprehensive review examines English literature identified through database search using Medline, Embase, Engineering Village, SPORTDiscus. results were classified based on MSC type, animal model, delivery/culture. A variety types, including bone marrow-derived, synovium-derived, adipose-derived, meniscus-derived MSCs, has examined. Research categorized into discussed by different models used; namely murine, leporine, porcine, caprine, bovine, ovine, canine, equine, human meniscus defect/repair. Within each studies further according delivery/culture techniques. These techniques included direct application, fibrin glue/gel/clot, intra-articular injection, scaffold, tissue-engineered construct, tissue, pellets/aggregates, hydrogel. purpose this inform reader about current state advances TE MSCs. Future directions MSC-based also suggested help guide prospective research.