Reduced pro-inflammatory responses to Staphylococcus aureus bloodstream infection and low prevalence of enterotoxin genes in isolates from patients on haemodialysis.
作者： S. McNicholas , A. Fe Talento , J. O’Gorman , M. M. Hannan , M. Lynch
DOI: 10.1007/S10096-016-2767-9
关键词:
摘要: Patients with end-stage renal failure undergo regular haemodialysis (HD) and often develop episodes of Staphylococcus aureus bloodstream infection (BSI), which can re-occur. However, clinically, patients on HD, S. BSI, respond well to treatment, rarely developing overt signs sepsis. We investigated the contributions bacterial virulence cytokine responses clinical course BSI in HD non-HD patients. Seventy were recruited, including 27 (38.6 %) HD. Isolates spa-typed antimicrobial resistance gene carriage was using DNA microarray analysis. Four inflammatory cytokines, IL-6, RANTES, GROγ leptin, measured patient plasma day diagnosis after 7 days. There no significant difference prevalence genotypes or genes isolates from compared The enterotoxin cluster (containing staphylococcal enterotoxins seg, sei, sem, sen, seo seu) significantly less prevalent among Comparing response patients, IL-6 lower (p = 0.021 p = 0.001, respectively) other RANTES levels (p = 0.025) following diagnosis. Lowered a reduced potential for super-antigen production by infecting may partly explain favourable that we noted clinically.
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