p21-activated kinase signaling in breast cancer

摘要: The p21-activated kinases signal through a number of cellular pathways fundamental to growth, differentiation and apoptosis. A wealth information has accumulated at an impressive pace in the recent past, both with regard previously identified targets for that regulate actin cytoskeleton stress newly their role cancer. Emerging data also provide new clues towards unappreciated link between these various processes. present review attempts quick tutorial reader about evolving significance small GTPases breast cancer, using from mouse models, tissue culture studies, human materials.