Mounting a strategic offense: fighting tumor vasculature with oncolytic viruses
作者： Fernando A. Angarita , Sergio A. Acuna , Kathryn Ottolino-Perry , Siham Zerhouni , J. Andrea McCart
DOI: 10.1016/J.MOLMED.2013.02.008
关键词:
摘要: Blood supply within a tumor drives progression and ultimately allows for metastasis. Many anticancer therapies target vasculature, but their individual effectiveness is limited because they induce indirect cell death. Agents that disrupt nascent and/or established vasculature while simultaneously killing cancer cells would certainly have greater impact. Oncolytic virotherapy utilizes attenuated viruses replicate specifically tumor. They cytotoxicity through combination of direct lysis, antitumor immune stimulation, recently identified vascular effects. This review summarizes the novel preclinical clinical evidence regarding effects oncolytic viruses, which include infection lysis endothelial cells, natural or genetically engineered antiangiogenic properties, therapy with clinically approved antivascular agents.
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