Brain tumor stem cell differentiation promoter, and therapeutic agent for brain tumor
作者： Hiroaki Ikushima , Tomoki Todo , Keiji Miyazawa , Kohei Miyazono , Yasushi Ino
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摘要: Disclosed is a pharmaceutical preparation which can reduce the tumorigenicity of glioma stem cell that has resistance against anti-cancer agents and radioactive rays increase sensitivity to rays. Specifically disclosed differentiation promoter comprises substance capable inhibiting TGF-β-Sox4-Sox2 pathway, i.e., pathway through TGF-β induce expression Sox4 promote Sox2, in cell.
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