Evaluation of an IFN-gamma assay in the diagnosis of latent tuberculosis in patients with psoriasis in a highly endemic setting.

摘要: Screening for latent tuberculosis infection is mandatory before starting anti-tumour necrosis factor treatments, but its diagnosis still poses a challenge. While studies performed in developed countries have demonstrated superior performance of T-cell based interferon-γ release assay (IGRA) compared with the tuberculin skin test, there debate about whether this holds true endemic areas. The an IGRA kit T-SPOT.TB was evaluated 33 moderate-to-severe untreated psoriasis patients and, as controls, 30 common dermatological diseases at highly setting. frequency positive test responses and induration size controls were higher than (53% vs. 18% 9.3 ± 1.4 2.6 0.7 mm, respectively, p < 0.001). In contrast, response mean number spots elicited not significantly different between (47% 43% 14.7 3.2 20.5 3.1 spots/well, respectively). two tests presented good agreement control, group (κ values 0.625 0.375, Thus, tuberculosis-endemic setting to diagnosing psoriasis, probably because immune dysregulation shows lower interference vitro test.