Antigenicity and cross-reactivity of 6-aminopenicillanic acid and penicillin G

摘要: A LLERGIC reactions to penicillin are a major clinical problem.‘, 2 Use of itself as skin test antigen is not adequate evaluate sensitization, since negative does exclude the existence allerg! and possibility reaction subsequent administration.” The identity antigenic components which determine sensitization prime importance for selection reagents diagnose sensitivity states accurately. molecular “nucleus” 6-aminopenicillanic acid (Fig. 1) . It can be isolated in pure form from fermentations, its formation by enzymatic hydrolysis has been demonstrated.* purpose this investigation was antigenicity 6aminopenicillanic rabbits cross-reactivity with penicillin, use tanned-cell hemagglutination passive cutaneous anaphylaxis techniques measurement antibody activity.