A penicilloylated protein impurity as a source of allergy to benzylpenicillin and 6-aminopenicillanic acid.

摘要: Abstract Fractionation of the sodium salt 6-aminopenicillanic acid (6-A.P.A.) led to isolation a high-molecular-weight material which gave strong passive cutaneous anaphylactic reactions in guineapigs. The " purified 6-A.P.A. no longer elicited response. It seems likely that this impurity derived from Escherichia coli preparation used production process. A similar proteinaceous was found commercially available benzylpenicillin. method for purifying benzylpenicillin developed. On storage however, substance developed and may be penicillin molecule by polymerisation. Thus, not all immunological activity penicillins is due penicilloylated protein. thought administration will reduce level induction hypersensitivity decrease number allergic manifestations if given inadvertently penicillin-sensitive patient. Purified should not, deliberately patient known sensitive. implications oral therapy are yet known.