Isolation and identification of ent-kaurane-type diterpenoids from Rabdosia serra (MAXIM.) HARA leaf and their inhibitory activities against HepG-2, MCF-7, and HL-60 cell lines
作者： Lianzhu Lin , Qing Gao , Chun Cui , Haifeng Zhao , Liwu Fu
DOI: 10.1016/J.FOODCHEM.2011.09.105
关键词:
摘要: Abstract A phytochemical investigation was conducted on Rabdosia serra leaf in this work. new ent -kaurane-type diterpenoid named 6β,14α-dihydroxy-1α,7β-diacetoxy-7α,20-epoxy- -kaur-16-en-15-one, together with 6 known compounds were identified, including parvifolin G, effusanin E, lasiodin, nodosin, β-sitosterol, and stigmasterol. It the first time that G E found R. . The assay of inhibition activity against HepG-2, MCF-7, HL-60 cell lines indicated 10 (including rosmarinic acid, methyl rosmarinate pedalitin which isolated previously), except stigmasterol, exhibited cytotoxicity tested tumour cells. inhibitory effects diterpenoids (except G) more effective than those sterols phenolics. Both -kaur-16-en-15-one lasiodin (IC 50
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