Antibacterial activity-guided purification and identification of a novel C-20 oxygenated ent-kaurane from Rabdosia serra (MAXIM.) HARA
作者： Lianzhu Lin , Dashuai Zhu , Linwu Zou , Bao Yang , Mouming Zhao
DOI: 10.1016/J.FOODCHEM.2013.01.001
关键词:
摘要: The objective of this work was to conduct an activity-guided isolation antibacterial compounds from Rabdosia serra. ethanol extracts R. serra leaf and stem were partitioned sequentially into petroleum ether, ethyl acetate, butanol water fractions, respectively. extract evidenced broad-spectrum activity against gram-positive bacterial, including Bacillus subtilis, cereus, Staphylococcus aureus, Listeria monocytogenes. acetate fractions exhibited strong inhibition bacteria, then purified further. On the basis assay-guided purification, three phenolic (rosmarinic acid, methyl rosmarinate pedalitin) four C-20 oxygenated ent-kauranes (effusanin E, lasiodin, rabdosichuanin D a new compound namely effusanin F) obtained, whose contents determined by HPLC analysis. broth microdilution method confirmed important potential with low minimum inhibitory concentration (MIC) values. Effusanin lasiodin F could be useful for development agents.
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sci-hub.se 参考文章(28)
Su-Ping Bai, Qing-Yi Wei, Xiao-Ling Jin, Quan-Xiang Wu, Li Yang, Two novel ent-kauranoid diterpenoids from Isodon japonica leaves. Planta Medica. ,vol. 71, pp. 764- 769 ,(2005) , 10.1055/S-2005-871246
Takahiko ISOBE, Kumiko NAGATA, The Study on the Antibacterial Activity of Compounds from the Isodon Species Yakugaku Zasshi-journal of The Pharmaceutical Society of Japan. ,vol. 130, pp. 447- 450 ,(2010) , 10.1248/YAKUSHI.130.447
Lianzhu Lin, Fenfen Lei, Da-Wen Sun, Yi Dong, Bao Yang, Mouming Zhao, Thermal inactivation kinetics of Rabdosia serra (Maxim.) Hara leaf peroxidase and polyphenol oxidase and comparative evaluation of drying methods on leaf phenolic profile and bioactivities. Food Chemistry. ,vol. 134, pp. 2021- 2029 ,(2012) , 10.1016/J.FOODCHEM.2012.04.008
Pengwei Liu, Yingfeng Du, Xiaowei Zhang, Xiaona Sheng, Xiaowei Shi, Chengcheng Zhao, Hong Zhu, Na Wang, Qiao Wang, Lantong Zhang, Rapid Analysis of 27 Components of Isodon serra by LC–ESI-MS–MS Chromatographia. ,vol. 72, pp. 265- 273 ,(2010) , 10.1365/S10337-010-1642-6
Shao-Min Wang, Yan-Bing Zhang, Hong-Min Liu, Guo-Bin Yu, Ke-Rang Wang, Mild and selective deprotection method of acetylated steroids and diterpenes by dibutyltin oxide Steroids. ,vol. 72, pp. 26- 30 ,(2007) , 10.1016/J.STEROIDS.2006.10.004
Lianzhu Lin, Qing Gao, Chun Cui, Haifeng Zhao, Liwu Fu, Liming Chen, Bao Yang, Wei Luo, Mouming Zhao, Isolation and identification of ent-kaurane-type diterpenoids from Rabdosia serra (MAXIM.) HARA leaf and their inhibitory activities against HepG-2, MCF-7, and HL-60 cell lines Food Chemistry. ,vol. 131, pp. 1009- 1014 ,(2012) , 10.1016/J.FOODCHEM.2011.09.105
EIICHI FUJITA, YOSHIMITSU NAGAO, KIMIYOSHI KANEKO, SHOZO NAKAZAWA, HIROYUKI KURODA, The antitumor and antibacterial activity of the Isodon diterpenoids. Chemical & Pharmaceutical Bulletin. ,vol. 24, pp. 2118- 2127 ,(1976) , 10.1248/CPB.24.2118
Karel Šmejkal, Stanislav Chudík, Pavel Klouček, Radek Marek, Josef Cvačka, Marie Urbanová, Ondřej Julínek, Ladislav Kokoška, Tereza Šlapetová, Pavla Holubová, Aleš Zima, Margita Dvorská, Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits. Journal of Natural Products. ,vol. 71, pp. 706- 709 ,(2008) , 10.1021/NP070446U
Lianzhu Lin, Chun Cui, Lingrong Wen, Bao Yang, Wei Luo, Mouming Zhao, Assessment of in vitro antioxidant capacity of stem and leaf extracts of Rabdosia serra (MAXIM.) HARA and identification of the major compound Food Chemistry. ,vol. 126, pp. 54- 59 ,(2011) , 10.1016/J.FOODCHEM.2010.10.060
Catalina S. Romano, Karina Abadi, Victoria Repetto, Adrián A. Vojnov, Silvia Moreno, Synergistic antioxidant and antibacterial activity of rosemary plus butylated derivatives Food Chemistry. ,vol. 115, pp. 456- 461 ,(2009) , 10.1016/J.FOODCHEM.2008.12.029