Cabozantinib (XL184), a Novel MET and VEGFR2 Inhibitor, Simultaneously Suppresses Metastasis, Angiogenesis, and Tumor Growth
作者： F. Michael Yakes , Jason Chen , Jenny Tan , Kyoko Yamaguchi , Yongchang Shi
DOI: 10.1158/1535-7163.MCT-11-0264
关键词:
摘要: … C, B16F10 cells were seeded in the upper chambers of a 96-well Transwell plate and … D, B16F10 cells were seeded in the upper chambers of a 96-well Transwell plate coated with …
aacrjournals.org
highwire.org参考文章(51)
Fadila Guessous, Alex Kofman, David Schiff, Ying Zhang, Roger Abounader, XL-184, a MET, VEGFR-2 and RET kinase inhibitor for the treatment of thyroid cancer, glioblastoma multiforme and NSCLC IDrugs : the investigational drugs journal. ,vol. 13, pp. 112- 121 ,(2010)
John M.L. Ebos, Christina R. Lee, William Cruz-Munoz, Georg A. Bjarnason, James G. Christensen, Robert S. Kerbel, Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis Cancer Cell. ,vol. 15, pp. 232- 239 ,(2009) , 10.1016/J.CCR.2009.01.021
Oriol Casanovas, Daniel J. Hicklin, Gabriele Bergers, Douglas Hanahan, Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors Cancer Cell. ,vol. 8, pp. 299- 309 ,(2005) , 10.1016/J.CCR.2005.09.005
H. Nechushtan, G. Edelman, G. Jerusalem, M. Gordon, H.M. Kluger, A. Moussa, I. Ron, F. Schimmoller, X. Shen, A. Daud, 398 Phase 2 results of XL184 in a cohort of patients (pts) with advanced melanoma Ejc Supplements. ,vol. 8, pp. 126- 127 ,(2010) , 10.1016/S1359-6349(10)72105-4
Tomas Kubiatowski, Taichang Jang, Mahesh B. Lachyankar, Rebecca Salmonsen, Roya R. Nabi, Peter J. Quesenberry, N. Scott Litofsky, Alonzo H. Ross, Lawrence D. Recht, Association of increased phosphatidylinositol 3-kinase signaling with increased invasiveness and gelatinase activity in malignant gliomas. Journal of Neurosurgery. ,vol. 95, pp. 480- 488 ,(2001) , 10.3171/JNS.2001.95.3.0480
Paolo Michieli, Massimiliano Mazzone, Cristina Basilico, Silvia Cavassa, Antonino Sottile, Luigi Naldini, Paolo M Comoglio, Targeting the tumor and its microenvironment by a dual-function decoy Met receptor Cancer Cell. ,vol. 6, pp. 61- 73 ,(2004) , 10.1016/J.CCR.2004.05.032
Bernard Escudier, Tim Eisen, Walter M Stadler, Cezary Szczylik, Stéphane Oudard, Michael Siebels, Sylvie Negrier, Christine Chevreau, Ewa Solska, Apurva A Desai, Frédéric Rolland, Tomasz Demkow, Thomas E Hutson, Martin Gore, Scott Freeman, Brian Schwartz, Minghua Shan, Ronit Simantov, Ronald M Bukowski, None, Sorafenib in advanced clear-cell renal-cell carcinoma. The New England Journal of Medicine. ,vol. 356, pp. 125- 134 ,(2007) , 10.1056/NEJMOA060655
Yoshihiko Kitajima, Takao Ide, Takao Ohtsuka, Kohji Miyazaki, Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer Cancer Science. ,vol. 99, pp. 1341- 1347 ,(2008) , 10.1111/J.1349-7006.2008.00828.X
Christina L. Roland, Sean P. Dineen, Kristi D. Lynn, Laura A. Sullivan, Michael T. Dellinger, Leila Sadegh, James P. Sullivan, David S. Shames, Rolf A. Brekken, Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts Molecular Cancer Therapeutics. ,vol. 8, pp. 1761- 1771 ,(2009) , 10.1158/1535-7163.MCT-09-0280
Gromoslaw A. Smolen, Raffaella Sordella, Beth Muir, Gayatry Mohapatra, Anne Barmettler, Heidi Archibald, Woo J. Kim, Ross A. Okimoto, Daphne W. Bell, Dennis C. Sgroi, James G. Christensen, Jeffrey Settleman, Daniel A. Haber, Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752 Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 2316- 2321 ,(2006) , 10.1073/PNAS.0508776103