Overexpression of bcl-2 protein in synovial sarcoma: A comparative study of other soft tissue spindle cell sarcomas and an additional analysis by fluorescence in situ hybridization
作者： Naoya Hirakawa , Takahiko Naka , Ichiro Yamamoto , Toshiro Fukuda , Masazumi Tsuneyoshi
DOI: 10.1016/S0046-8177(96)90284-1
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摘要: The expression of bcl-2 protein was analyzed in 19 synovial sarcomas and 29 additional soft tissue spindle cell as controls by the immunohistologic staining paraffin-embedded specimens; 15 (79%) sarcoma cases were positive, but all other negative including 20 leiomyosarcomas, 4 malignant peripheral nerve sheath tumors, fibrosarcomas. In bcl-2-positive (3 biphasic 1 focally glandular type), much stronger cells than epithelial cells. A fluorescence situ hybridization (FISH) analysis with centromeric whole chromosome painting probes for 18 X performed on 7 sarcomas. six consisted five t(X; 18) one case tetrasomy X. It has been speculated that is caused 14; translocation abnormalities 18. This study thus showed feasibility such a correlation between characteristic cytogenetic abnormality sarcoma-X; translocation. addition, also appears to be marker considered potentially useful distinguishing from
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