Paclitaxel-induced neuropathic hypersensitivity in mice: responses in 10 inbred mouse strains.

摘要: Mechanical allodynia, or hypersensitivity to tactile stimuli, is a frequent clinical symptom of neuropathy. Large interindividual differences have been observed in neuropathic pain, both susceptibility its development and severity. Identification genetic factors relevant this variability would be obvious utility. Although many animal models pain following peripheral nerve injury developed, most involve intricate surgeries are thus poorly suited for large-scale linkage mapping investigations the mouse. Recently, schedule intraperitoneal injections chemotherapeutic agent, paclitaxel (Taxol®), has shown produce long-lasting, bilateral neuropathy rat, featuring mechanical, thermal cold stimuli. We present here survey responses 10 inbred mouse strains injections. Virtually all developed statistically significant mechanical with one strain, DBA/2J, exhibiting especially robust changes. Strain sensitivities paclitaxel-induced allodynia were similar those obtained previously using surgical model supporting our contention that sensitivity independent precise mode induction. Using sensitive DBA/2 mice resistant C57BL/6J, comparison, we further characterized by examining hyperalgesia. Both displayed equivalent but neither strain The data confirm component model, while dissociating from other modalities.