Calcitonin Receptors on Cultured Human Lymphocytes

摘要: SUMMARY Established human lymphoid cell lines bound calcitonin with high affinity. Calcitonin binding was detectable on both B and T derived from patients a spectrum of lymphoproliferative disorders. These had marked differences in capacity per even when adjusted for surface area. The linearly related to density showed complex temperature dependency. Steady state kinetic analysis suggested single class affinity receptors an apparent association constant 4 x lOlo MP. Competitive studies analogs revealed order Ki values similar those previously obtained using plasma membranes known target tissues. Human calcitonin, as found renal or skeletal the rat, competed only weakly lymphocyte confirming that analog has evolved into weak unstable form, both.