The role of lymphokines in immunogenic uveitis.

摘要: Lymphokines were prepared from rabbit lymph node cells specifically activated in vitro with the insoluble antigen ovalbumin or nonspecifically mitogen concanavalin A. Intravitreal injection of either lymphokine caused uveitis normal eye, more severe and prolonged A-activated supernatants than ovalbumin-activated supernatants. The most striking difference between two preparations was their ability to induce a secondary intraocular antibody response trinitrophenyl bovine gamma globulin-primed recipient. Concanavalin A stimulated polyclonal B cell activation appreciable anti-TNP responses animals primed systemically locally. In contrast, an only those that had been within eye. We speculate different lymphokines are active, some which attract lymphocytes local site others excite plasma formation.