Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds.

摘要: Background Increased knowledge of the evolution molecular changes in neurodegenerative disorders such as Alzheimer's disease (AD) is important for understanding pathophysiology and also crucial to be able identify validate biomarkers. While several biological that occur early development have already been recognized, need further characterization pathophysiological mechanisms behind AD still remains. Methods In this study, we investigated cerebrospinal fluid (CSF) levels 104 proteins 307 asymptomatic 70-year-olds from H70 Gothenburg Birth Cohort Studies using a multiplexed antibody- bead-based technology. Results The protein were first correlated with core CSF biomarker concentrations total tau, phospho-tau amyloid beta (Aβ42) all individuals. Sixty-three showed significant correlations either or Aβ42. Thereafter, individuals divided based on Aβ42/Aβ40 ratio Clinical Dementia Rating (CDR) score determine if pathology cognition had an effect correlations. We compared associations analysed markers between groups found 33 displaying significantly different amyloid-positive amyloid-negative individuals, defined by ratio. No differences could seen CDR score. Conclusions identified series transmembrane proteins, associated anchored plasma membrane, involved connected synaptic vesicle transport biomarkers tau AD. Further studies are needed explore these proteins' role pathophysiology.