True deficiency of antioxidant vitamins E and A in dialysis patients. Relationship with clinical patterns of atherosclerosis.

摘要: Atherosclerosis is an important cause of morbidity and mortality in peritoneal dialysis (PD) patients. Oxidative stress plays a role the pathogenesis uremic atherosclerosis. Although antioxidant substances (vitaminsA E) are elevated plasma patients, intracellular clinical signs hypovitaminosis frequently found. Recently, importance vitamin/carrier complexes as marker vitamin bioavailability has been demonstrated. In present study, we analyzed A E bioavailability, measured vitamin/ carrier complexes, relationship those measurements with atherosclerosis status PD We studied 45 patients (15 men, 30 women), who were divided into four groups according to atherosclerotic score (CAS). Five cases scored CAS grade I (low CAS); 9 CAS-2; 18 CAS-3; 13 CAS-4. Vitamins their carriers [prealbumin retinol binding protein (vitamin A), cholesterol triglycerides E)] determined. Plasma levels low 5 normal 7 high 33 By correcting values for levels, created three groups: 24 showed A/ complex (5 from group, 6 normal-value high-value group); 11 group A/carrier (1 10 A/carrier. The statistically significant, negative linear correlation serum iron. Low found 1 patient, 28 16 When corrected using values, also created. E/carrier contained low-value 22 group). 21 univariate logistic regression analysis, significant associations between E/carrier, age, albumin multiple confirmed that complex, independent CAS, but not vitamin-only levels. Our results show disorder mobilization pool target cells. findings other researchers about deficiencies may change traditional concept hypervitaminosis