Risk of Acute Nonlymphocytic Leukemia and Preleukemia in Patients Treated with Cyclophosphamide for Non-Hodgkin's Lymphomas
作者： JENS PEDERSEN-BJERGAARD
DOI: 10.7326/0003-4819-103-2-195
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摘要: Of 602 patients treated for non-Hodgkin's lymphomas, 9 developed overt acute nonlymphocytic leukemia or preleukemia with refractory cytopenia and cytogenetic abnormalities of the bone marrow. A Kaplan-Meier estimate cumulative probability leukemic complications was 6.3 +/- 2.6% (mean SE) 7 years after start treatment. All belong to a major subgroup 498 alkylating agents, predominantly cyclophosphamide. The risk in this compared 312 other agents Hodgkin's disease, 553 dihydroxybusulfan ovarian carcinoma. Cumulative 9-year risks were 8.0 3.3%, 12.8 3.5%, 7.1 1.9%, respectively. general secondary long-term treatment ranges from 1% 1.5% per year 2 at least
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