Rheological and syringeability properties of highly concentrated human polyclonal immunoglobulin solutions
作者： V. Burckbuchler , G. Mekhloufi , A. Paillard Giteau , J.L. Grossiord , S. Huille
DOI: 10.1016/J.EJPB.2010.08.002
关键词:
摘要: This study of highly concentrated polyvalent immunoglobulin solutions, IgG, aimed at analyzing the relationships between protein concentration and aggregation on one hand viscosity other hand. Viscosity variations as a function IgG showed two well-defined behaviours: Newtonian behaviour for low-concentrated solutions shear-thinning ones. The data fitted very well with Mooney model, suggesting absence intermolecular interactions in that behaved like non-interacting suspension hard particles. polyclonal nature seems to prevent interaction. shape factor, determined from fitting, revealed non-spherical molecules. rheological properties were also correlated injection force (F) through hypodermic needles by syringeability tests. Here, F was mainly affected three parameters: solution viscosity, flow rate, needle characteristics. In fact, tests increased rate decreased internal diameter needle. A zone optimal conditions then identified taking into account different affecting parameters maximum manual injection, which fixed 30N.
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