Recurrent glomerulonephritis after renal transplantation.

摘要: Purpose of review The current understanding the incidence, predisposing factors, pathophysiology and effective treatment recurrent glomerulonephritis (RGN) in renal transplants remains at best patchy worst, completely lacking. Current reports have been limited by inconsistencies study design, sample populations lengths follow-up. Making sense available evidence will provide tools to support transplant nephrologists their management allograft donors recipients. Recent findings With better survival allografts, RGN has become a dominant factor influencing survival. Evidently, risk recurrence is proportional incremental time posttransplantation. proposed factors for include but are not severity primary (PGN), younger recipient age, live-related donor allograft, minimal HLA mismatch, steroid avoidance nonuse induction therapy. Unfortunately, these derived from retrospective cohort registry studies; hence, true causality hard prove. Summary improving, as we gain greater its pathophysiology, including genetic, alloimmune autoimmune contributions recurrence. pretransplant stratification, posttransplant surveillance, novel biomarkers new strategies, hope community eventually predict risk, prevent personalise RGN.