Immunohistochemical study of sialyl lea and sialyl lex antigen in oral squamous cell carcinoma: The association of sialyl lea expression with the metastatic potential
作者： Shin-ichi Kurahara , Masanori Shinohara , Tetsuro Ikebe , Seiji Nakamura , Akimitu Hiraki
DOI: 10.1002/(SICI)1097-0347(199907)21:4<330::AID-HED7>3.0.CO;2-#
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摘要: Background. Carbohydrate antigens in cancer cells are considered to be involved the binding of endothelium during metastasis. Methods. Seventy cases primary oral squamous cell carcinoma (SCC) were obtained from biopsy specimens and analyzed immunohistochemically using an antibody against sialyl Lewis (Le) a or Le x . Flow cytometry was performed detect expressed on SCC lines. Results. The expressions , but not tumors significantly correlated nodal metastasis; 71% metastatic express with positive no demonstrated high incidence metastasis (80%). A flow cytometric study line, which can metastasize nude mice, level Conclusion. expression may thus therefore predict poor prognosis SCC.
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sci-hub.se 参考文章(23)
Morris Fishbein (), Interferon treatment of human neoplasia. Advances in Cancer Research. ,vol. 46, pp. 1- 265 ,(1986) , 10.1016/S0065-230X(08)60034-2
Lance A. Liotta, Tumor Invasion and Metastases—Role of the Extracellular Matrix: Rhoads Memorial Award Lecture Cancer Research. ,vol. 46, pp. 1- 7 ,(1986)
Nobuyuki Kamata, Toshio Kuroki, Masaru Horikoshi, Kazuhiro Chida, Shoji Enomoto, Koichi Rikimaru, Growth-inhibitory Effects of Epidermal Growth Factor and Overexpression of Its Receptors on Human Squamous Cell Carcinomas in Culture Cancer Research. ,vol. 46, pp. 1648- 1653 ,(1986)
Tatsuro Irimura, Takao Yamori, Sen-itiroh Hakomori, Karen R. Cleary, Yoshifumi Matsushita, David M. Ota, Stuart D. Hoff, Increased expression of sialyl-dimeric LeX antigen in liver metastases of human colorectal carcinoma. Cancer Research. ,vol. 49, pp. 6883- 6888 ,(1989)
E.L. Berg, M.K. Robinson, O. Mansson, E.C. Butcher, J.L. Magnani, A carbohydrate domain common to both sialyl Le(a) and sialyl Le(X) is recognized by the endothelial cell leukocyte adhesion molecule ELAM-1. Journal of Biological Chemistry. ,vol. 266, pp. 14869- 14872 ,(1991) , 10.1016/S0021-9258(18)98555-8
W Gillespie, S Kelm, J.C. Paulson, Cloning and expression of the Gal beta 1, 3GalNAc alpha 2,3-sialyltransferase. Journal of Biological Chemistry. ,vol. 267, pp. 21004- 21010 ,(1992) , 10.1016/S0021-9258(19)36789-4
Junko Nishikata, Reiji Kannagi, Shigeki Arii, Shigeyuki Itai, Takayoshi Tobe, Osamu Tanaka, Shizuo Hasegawa, Yoshito Matsubara, Noboru Yanai, Kazuo Takaoka, Naofumi Takahashi, Differentiation-dependent expression of I and sialyl I antigens in the developing lung of human embryos and in lung cancers. Cancer Research. ,vol. 50, pp. 7603- 7611 ,(1990)
A Hiraki, M Shinohara, T Ikebe, S Nakamura, S Kurahara, DR Garrod, Immunohistochemical staining of desmosomal components in oral squamous cell carcinomas and its association with tumour behaviour British Journal of Cancer. ,vol. 73, pp. 1491- 1497 ,(1996) , 10.1038/BJC.1996.282
Akiko Takada, Katsuyuki Ohmori, Naofumi Takahashi, Kiyotaka Tsuyuoka, Akihiro Yago, Koichi Zenita, Akira Hasegawa, Reiji Kannagi, Adhesion of human cancer cells to vascular endothelium mediated by a carbohydrate antigen, sialyl Lewis A. Biochemical and Biophysical Research Communications. ,vol. 179, pp. 713- 719 ,(1991) , 10.1016/0006-291X(91)91875-D
Kazuhiro Iwai, Hiroshi Ishikura, Mitsuhito Kaji, Hiroshi Sugiura, Akihiro Ishizu, Chisa Takahashi, Hiroyuki Kato, Tatsuzo Tanabe, Takashi Yoshtki, Importance of E‐selectin (ELAM‐1) and sialyl lewisa in the adhesion of pancreatic carcinoma cells to acttvated endothelium International Journal of Cancer. ,vol. 54, pp. 972- 977 ,(1993) , 10.1002/IJC.2910540618