Adrenal Vein Catecholamine Levels and Ratios: Reference Intervals Derived from Patients with Primary Aldosteronism.

摘要: Phaeochromocytoma localisation is generally reliably achieved with modern imaging techniques, particularly in sporadic cases. On occasion, however, there can be diagnostic doubt due to the presence of bilateral adrenal abnormalities, patients mutations genes predisposing them development multiple phaeochromocytomas. In such cases, surgical intervention ideally limited large or functional lesions long-term consequences associated hypoadrenalism. Adrenal venous sampling (AVS) for catecholamines has been used this situation guide surgery, although are few data available support thresholds. Retrospective analyses AVS results from 2 centres were carried out. A total 172 (88 men, 84 women) underwent under cosyntropin stimulation diagnosis established primary aldosteronism (PA) measurement and peripheral cortisol, aldosterone catecholamines. Six (3 3 phaeochromocytoma purposes subsequent histological confirmation. Reference intervals norepinephrine epinephrine ratio created PA group. Using 97.5th centile (1.21 on left, 1.04 right), false negative rate group was 0%. conclusion, study describes largest dataset catecholamine measurements provides reference without phaeochromocytoma. This strengthens certainty which conclusions related drawn, acknowledging procedure not part routine workup an adjunct use only difficult clinical