Inhibitory conductance changes and action of γ-aminobutyrate in rat hippocampus

摘要: Abstract Inhibitory synaptic potentials (IPSPs) and underlying resistance (and conductance) changes were examined in CA1 CA3 hippocampal neurons situ rats. Comparable large conductance increases evoked by fimbrial-commissural or entorhinal stimulation, the corresponding inhibitory had similar reversal potentials. The peak intensity duration of potential change both greater under urethane than ketamine anaesthesia. A striking rebound conductance, commonly seen at end potentials, was Cl − sensitive could be ascribed to a prolonged suppression ongoing input. time course significantly voltage-sensitive, being more for negative positive Applications γ-aminobutyrate produced (mean potency 4.2 nS/nA iontophoretic current). There excellent agreement between effect γ-aminobutyrate, recorded same cells. As elsewhere showed marked fading during applications lasting few seconds. By contrast, glycine seldom caused definite increase but it appeared depress probably an indirect action.