Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients

摘要: Abstract Dysfunction of the central nervous system (CNS) is a prominent feature acquired immune deficiency syndrome (AIDS). Many these patients have subacute encephalitis consistent with viral infection CNS. We studied brains 12 AIDS using in situ hybridization to identify human immunodeficiency virus [HIV, referred by others as T-cell lymphotropic type III (HTLV-III), lymphadenopathy-associated (LAV), AIDS-associated retrovirus (ARV)] nucleic acid sequences and immunocytochemistry cellular proteins. Nine had significant HIV In all examined brains, white matter was more severely involved than grey matter. most cases restricted capillary endothelial cells, mononuclear inflammatory giant cells. single case severe CNS involvement, low-level seen some astrocytes neurons. These results suggest that dysfunction due indirect effects rather neuronal or glial infection.