Green Extraction of Alkaloids and Polyphenols from Peumus boldus Leaves with Natural Deep Eutectic Solvents and Profiling by HPLC-PDA-IT-MS/MS and HPLC-QTOF-MS/MS
作者： Jeniffer Torres-Vega , Sergio Gómez-Alonso , José Pérez-Navarro , Edgar Pastene-Navarrete
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摘要: Peumus boldus Mol., is a Chilean medicinal tree used for gastrointestinal and liver diseases. Such properties are associated with the presence of bioactive flavonoids aporphine alkaloids. In this study, new green efficient extraction method seven natural deep eutectic solvents (NADES) as media. The efficiency these NADES was assessed, determining contents boldine total phenolic compounds (TPC). Chemical profiling P. done by high-performance liquid chromatography coupled to photo diode array detector electrospray ion-trap mass spectrometry (HPLC-PDA-ESI-IT/MS) ionization quadrupole time-of-flight high-resolution (HPLC-ESI-QTOF-MS). Among tested, NADES4 (choline chloride-lactic acid) NADES6 (proline-oxalic enable better 0.427 ± 0.018 2.362 0.055 mg g-1 plant, respectively. Extraction more than extractions performed methanol water. On other hand, highest TPC were obtained using NADES6, 179.442 3.79 gallic acid equivalents (GAE g-1). Moreover, in extracts does not show significant differences NADES6. HPLC-PAD-MS/MS analysis tentative identification 9 alkaloids 22 compounds. results study demonstrate that promising media extract could be valuable alternative classic organic solvents.
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