MicroRNA-30a attenuates mutant KRAS-driven colorectal tumorigenesis via direct suppression of ME1
作者： Hongxing Shen , Chuan Xing , Kaisa Cui , Yunxiao Li , Jinxiang Zhang
DOI: 10.1038/CDD.2017.63
关键词:
摘要: Frequent KRAS mutations contribute to multiple cancers including ~40% of human colorectal (CRCs). Systematic screening 1255 microRNAs (miRNAs) identified miR-30a as a synthetic lethal in KRAS-mutant CRC cells. was downregulated CRCs and repressed by P65. directly targeted malic enzyme 1 (ME1) KRAS, inhibited anchorage-independent growth vivo tumorigenesis ME1 significantly upregulated CRCs. Eliminating short hairpin RNA (shRNA) resulted obviously decreased NADPH production, levels triglyceride fatty acid, an inhibition tumorigenicity overexpression suppression attenuated AOM/DSS-induced tumorigenesis. The critical roles the development indicate therapy potentials for this subtype cancer.
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