Capillary TSH screening programme for Down's syndrome in Scotland, 1997–2009

摘要: Objectives To assess uptake of community-based capillary thyroid stimulating hormone (TSH) screening in Scotland and determine the optimal frequency screening, justification for preschool strategies treatment. Methods Subjects with Down9s syndrome aged 1–19 years underwent TSH measurement. Clinical biochemical data were collected using proformas. Results 5742 tests performed on 1329 children 1997–2009, increasing from 183 two health boards tested 1997 to 630 13 2009. Of 132 referred by laboratory elevated TSH, 98 (M:F ratio 1:1.2, median (range) age 8.9 (0.9–17.9) years) had adequate documentation 76 dysfunction (defined as venous >6 mU/l), giving a prevalence not less than 5.7%. Fifty-six (57%) negative during previous year, 8 (8%) positive their first test 23/67 (34%) peroxidase autoantibody initial blood. Two (13%) severely hypothyroid (venous 71 283 mU/l). patients 6–10.9 (n=27), 11.0–20.9 (n=25) ≥21.0 mU/l (n=24) following referral, initial/subsequent treatment thyroxine was given 3/8, 15/5 21/1, respectively. Conclusion Capillary is eminently feasible should be annually 1 year age. Nearly all subjects ≥11.0 will require but most 6–10 only surveillance initially.