作者: Lars Winther , Susanne Gabs , Kenneth Heesche Petersen , Jesper Lohse
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摘要: The invention provides compositions and methods for the detection of targets in a sample; particular, an immunohistochemistry (IHC) sample. Probes detectable labels may be provided multiple layers order to increase flexibility system, allow amplification enhance signal from target. created by incorporating probes into larger molecular units that interact through nucleic acids base-pairing, including peptide-nucleic acid (PNA) base-pairing. Optional non-natural bases degenerate base pairing schemes. are compatible with (IHC), but also could used immunocytochemistry (ICC), situ hybridization (ISH), flow cytometry, enzyme immuno-assays (EIA), linked (ELISA), blotting (e.g. Western, Southern, Northern), labeling inside electrophoresis systems or on surfaces arrays, precipitation, among other general assay formats. is many different types targets, probes, labels.