Pharmacology of the human saphenous vein.

摘要: Nowadays, the great saphenous vein is vascular conduit that most frequently employed in coronary and peripheral revascularization surgery. It known bypass grafts have shorter patency than arterial ones, partly because wall of normal has different structural functional characteristics. The features this can be affected by large distention pressures it submitted to during its preparation insertion into system. Indeed, a graft subjected considerable changes hemodynamic forces upon implantation circulation, since transplanted from non-pulsatile, low-pressure, low-flow environment with minimal shear stress highpressure system pulsatile flow, where undergoes cyclic strain elevated shear. These responsible for morphological alterations vessel wall, culminating intima hyperproliferation atherosclerotic degeneration, which contribute early thrombosis. This review followed predetermined strategy updating information on human (HSV). Besides presenting aspects relative basic pharmacology, text also includes surgical concerning HSV harvesting, possible effects major groups cardiovascular drugs HSV, finally interference diseases reactivity HSV.