The role of TRAF6 in signal transduction and the immune response
作者： Takashi Kobayashi , Matthew C. Walsh , Yongwon Choi
DOI: 10.1016/J.MICINF.2004.09.001
关键词:
摘要: Signals from the IL-1 receptor (IL-1R)/Toll-like (TLR) family and TNF (TNFR) superfamily are critical for regulating function of antigen-presenting cells such as dendritic (DCs). It has been revealed that receptor-associated factor 6 (TRAF6), a signaling adapter molecule common to IL-1R/TLR TNFR superfamily, is important not only DC maturation, cytokine production, T cell stimulatory capacity DCs in response TLR ligands (e.g. lipopolysaccharide) or CD40 ligand, but also homeostasis splenic subsets.
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