Host CCL3L1 Gene Copy Number in Relation to HIV-1-Specific CD4 + and CD8 + T-Cell Responses and Viral Load in South African Women

摘要: HIV-specific T-cell responses play an important role in control of infection. Because CCL3 has immune modulatory and antiviral activities, we hypothesized that host genotype (CCL3L1 gene duplications) would influence the development effective responses. Copy numbers CCL3L1 were determined for 71 HIV-infected women, CD4 CD8 to overlapping peptide pools spanning HIV-1 subtype C genome simultaneously measured by interferon-gamma interleukin-2 whole-blood flow cytometric assay. Host copy number correlated negatively with viral load (r=-0.239, P=0.045), as did magnitudes Gag (r=-0.362, P=0.002) (r=-0.261, P=0.028) Patients a response (P=0.002) or dominant (P=0.006) had significantly lower loads than those whose targeted another region genome, whereas Nef-specific was associated higher HIV load. greater equal population median 5 increased magnitude (P=0.017), women who Gag-specific (P=0.004) (P=0.015) only