Human Immunodeficiency Virus Type 1 Envelope–Stimulated Interleukin-2 Production and Survival of Infected Children with Severe and Mild Clinical Disease

摘要: Interleukin (IL)-2 production after stimulation with human immunodeficiency virus type 1 (HIV-1) envelope (Env) peptides, tetanus toxoid, and phytohemagglutinin was measured in peripheral blood mononuclear cells (PBMC) from 25 HIV-1-infected children mild 24 severe clinical disease 15 uninfected children. Env-specific IL-2 detected PBMC of 26.5% but none the uninfected. The absence responses at enrollment among infected associated a 6-fold increased risk mortality within year, adjusting for severity (P = .04). Among those disease, Env-stimulated reactivity negatively correlated HIV-1 RNA copy numbers plasma positively CD4 T cell percentages year later. HIV-specific cellular immune may play role containing progression infection children, despite early deficits cell-mediated immunity.