Helper T-cell responses in children infected with human immunodeficiency virus type 1.
作者： Emmanuel Roilides , Mario Clerici , Louis DePalma , Marc Rubin , Philip A. Pizzo
DOI: 10.1016/S0022-3476(05)80033-2
关键词: Toxoid 、 Virology 、 Peripheral blood mononuclear cell 、 T cell 、 Medicine 、 Virus 、 Antigen 、 Tetanus 、 Interleukin 2 、 Human leukocyte antigen 、 Immunology
摘要: Helper T-cell function was evaluated in 34 children infected with human immunodeficlency virus type 1, by assessing interleukin-2 production after stimulation of peripheral blood mononuclear cells recall antigens (influenza virus, tetanus toxoid), allogeneic HLA, and phytohemagglutinin. In addition, helper correlated retrospectively the incidence opportunistic bacterial infections. Four patterns were observed: (1) 7 (21%) responded to all stimuli, (2) them alloantigens phytohemagglutinin but not antigens, (3) or alloantigens, (4) 13 (37%) did respond any these stimuli. There no significant differences related different routes acquisition among patients. Patients functional defects had a history more ( p =0.03)
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