Molecular Characterization of HEV Genotype 3 in Italy at Human/Animal Interface

摘要: Hepatitis E virus (HEV) is an emerging public health issue in industrialized countries. In the last decade number of autochthonous human infections has increased Europe. Genotype 3 (HEV-3) typically zoonotic, being foodborne main route transmission to humans, and most frequently detected Europe both humans animals (mainly pigs wild boars). Italy, first case was reported 1999; since then, HEV-3 been widely animals. Despite zoonotic characteristic well established, correlation between animal strains poorly investigated Italy. present study, we compared subtype distribution (swine boar) period 2000-2018 from The dataset for this analysis included a total 96 Italian ORF2 sequences (300 nt long), including NCBI database-derived (n = 64) recent (2016-2018, n 32) obtained study. results show that 3f frequent pigs, followed by HEV-3e, HEV-3c other unassignable strains. Diversely, boar wider group subtypes have detected, HEV-3a, which also time patient Central Italy 2017, wide phylogenetic including, besides strains, countries retrieved database, indicated sequences, particular those HEV-3f form significant clusters mainly with origin same country. Nevertheless, HEV-3c, rarely are more correlated European Furthermore, near-identical identified short interval Lazio Region (Central Italy) can be recognized tree, suggesting multiple originating common source occurred, confirming importance sequencing support HEV surveillance.