XISTunmethylated DNA fragments in male-derived plasma as a tumour marker for testicular cancer
作者： Takahiro Kawakami , Keisei Okamoto , Osamu Ogawa , Yusaku Okada
DOI: 10.1016/S0140-6736(03)15170-7
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摘要: Summary Testicular germ-cell tumours (TGCTs) are the most common malignant diseases among young men, with peak incidence at age 20–40 years. We developed a DNA tumour marker for TGCTs based on unmethylated profile of neoplasm. The 5′ end XIST gene is mainly hypomethylated in irrespective expression. Male somatic cells, however, show complete methylation through CpG sites, including minimum promoter and XIST-conserved repeats. Identification fragment male plasma might be diagnostic TGCTs.
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