Distinct epigenetic phenotypes in seminomatous and nonseminomatous testicular germ cell tumors

摘要: The genetic nature of testicular germ cell tumors and the molecular mechanisms underlying morphological clinical differences between two subtypes, seminomas nonseminomas, remains unclear. Genetic studies show that both subtypes exhibit many same regional genomic disruptions, although frequencies vary few clear are found. We demonstrate significant epigenetic nonseminomas by restriction landmark scanning. Seminomas almost no CpG island methylation, in contrast to methylation at a level similar other solid tumors. find an average 1.11% islands but only 0.08% methylated seminomas. Furthermore, we more highly hypomethylated than throughout their genome. Since thought arise from primordial cells, seen these may reflect normal developmental switch cells undermethylated genome normally discuss findings relation different models for seminomatous nonseminomatous