Urinary hydroxypyridinium cross-links of collagen in primary hyperparathyroidism
作者： M J Seibel , F Gartenberg , S J Silverberg , A Ratcliffe , S P Robins
DOI: 10.1210/JCEM.74.3.1740480
关键词:
摘要: Urinary concentrations of the collagen cross-links, pyridinoline (PYD) and deoxypyridinoline (DPD), were determined in 87 patients with untreated or surgically treated primary hyperparathyroidism (PHPT). Eighty-four healthy individuals, matched for age sex, constituted control group excretion pyridinium cross-links. In addition, a subgroup 25 PHPT was followed longitudinally up to 2 yr after successful parathyroidectomy. Mean urinary PYD (46.8 +/- 2.7 nmol/mmol creatinine) DPD (17.6 1.3 significantly higher than normal subjects (P less 0.001). undergoing parathyroidectomy, mean (34 2.5) (9.4 0.8) similar those controls lower patient population The concentration both cross-links correlated serum levels alkaline phosphatase PTH. cross-link compounds decreased within 6 months as early weeks surgery individual compared presurgical baseline values. These changes preceded reduction hydroxyproline by approximately months. results demonstrate that hydroxypyridinium are useful indices clinical assessment bone involvement PHPT.
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sci-hub.se 参考文章(21)
S P Robins, An enzyme-linked immunoassay for the collagen cross-link pyridinoline Biochemical Journal. ,vol. 207, pp. 617- 620 ,(1982) , 10.1042/BJ2070617
DAVID C. LEPPLA, WILLIAM SNYDER, CHARLES Y.C. PAK, Sequential changes in bone density before and after parathyroidectomy in primary hyperparathyroidism. Investigative Radiology. ,vol. 17, pp. 604- 606 ,(1982) , 10.1097/00004424-198211000-00013
Pierre D. Delmas, Annette Schlemmer, Evelyne Gineyts, Bente Riis, Claus Christiansen, Urinary excretion of pyridinoline crosslinks correlates with bone turnover measured on iliac crest biopsy in patients with vertebral osteoporosis. Journal of Bone and Mineral Research. ,vol. 6, pp. 639- 644 ,(2009) , 10.1002/JBMR.5650060615
C Nagant de Deuxchaisnes, J P Devogelaer, J P Huaux, Long-term Follow Up of Untreated Primary Hyperparathyroidism BMJ. ,vol. 290, pp. 64- 65 ,(1985) , 10.1136/BMJ.290.6461.64
Carlos Mautalen, Harry Romero Reyes, Gualterio Ghiringhelli, Günther Fromm, Cortical bone mineral content in primary hyperparathyroidism. Changes after parathyroidectomy. European Journal of Endocrinology. ,vol. 111, pp. 494- 497 ,(1986) , 10.1530/ACTA.0.1110494
Anders Linde, Simon P. Robins, Quantitative Assessment of Collagen Crosslinks in Dissected Predentin and Dentin Collagen and Related Research. ,vol. 8, pp. 443- 450 ,(1988) , 10.1016/S0174-173X(88)80017-7
S.P. ROBINS, D. BLACK, C.R. PATERSON, D.M. REID, A. DUNCAN, M.J. SEIBEL, Evaluation of urinary hydroxypyridinium crosslink measurements as resorption markers in metabolic bone diseases. European Journal of Clinical Investigation. ,vol. 21, pp. 310- 315 ,(1991) , 10.1111/J.1365-2362.1991.TB01375.X
Ina N. Cholst, Susan F. Steinberg, Pamela J. Tropper, Harold E. Fox, Gino V. Segre, John P. Bilezikian, The Influence of Hypermagnesemia on Serum Calcium and Parathyroid Hormone Levels in Human Subjects New England Journal of Medicine. ,vol. 310, pp. 1221- 1225 ,(1984) , 10.1056/NEJM198405103101904
Shonni J Silverberg, Elizabeth Shane, Luz de la Cruz, David W Dempster, Frieda Feldman, David Seldin, Thomas P Jacobs, Ethel S Siris, Maureen Cafferty, May V Parisien, Robert Lindsay, Thomas L Clemens, John P Dr. Bilezikian, None, Skeletal disease in primary hyperparathyroidism. Journal of Bone and Mineral Research. ,vol. 4, pp. 283- 291 ,(2009) , 10.1002/JBMR.5650040302
Daniel Uebelhart, Evelyne Gineyts, Marie-Claire Chapuy, Pierre D. Delmas, Urinary excretion of pyridinium crosslinks: a new marker of bone resorption in metabolic bone disease. Bone and Mineral. ,vol. 8, pp. 87- 96 ,(1990) , 10.1016/0169-6009(91)90143-N