Bioguided investigation of the antimalarial activities of Trema orientalis (L.) Blume leaves
作者： O.O. Samuel , B. , Oluyemi , W. and Abiodun
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摘要: Malaria remains a major public health concern which affects millions of people, particularly in Sub-Saharan Africa. The need for the development alternate treatment means has become critical because emergence resistance to nearly all antimalarial drugs (Kim and Schneider, 2013). Trema orientalis (L.) Blume (Ulmaceae) is used locally malaria. This study was designed determine anti-plasmodial activity acetone extract T. carry out bio-guided separation extract. Acetone leaves investigated its mouse model Plasmodium berghei using 4 day suppressive test. Bioguided investigation carried by column chromatographic fractions in-vivo antiplasmodial screening. Preliminary spectroscopic profile most active fraction obtained. Treatment with graded doses (100 800 mg/Kg) resulted significant chemosuppression parasite growth that ranged from 44.0 83.8%. identified as M6 showed schizontocidal (P < 0.001). 1H NMR Infrared spectra data indicated contained flavonoids. justified folkloric use orientalis. Compounds this plant could be potential source agents. Key words: Antimalarial, PCV, berghei, anaemia,
sci-hub.se 参考文章(14)
Kiseko Kamei, Hiroyuki Matsuoka, Akira Ishii, Toshihiro Shibuya, Seiji Mogi, Ryu-ichi Fujisaki, Naoko Aoki, Syun-ichi Furuhata, Tomotaka Kawakami, Hisanao Yoshihara, Anti-malarial activity of leaf-extract of hydrangea macrophylla, a common Japanese plant. Acta Medica Okayama. ,vol. 54, pp. 227- 232 ,(2000) , 10.18926/AMO/32291
D. J. Knight, W. Peters, The antimalarial activity of N-benzyloxydihydrotriazines. I. The activity of clociguanil (BRL 50216) against rodent malaria, and studies on its mode of action. Annals of Tropical Medicine and Parasitology. ,vol. 74, pp. 393- 404 ,(1980) , 10.1080/00034983.1980.11687360
B. Samuel, J. Okogun, K. Idowu, A. A. Olaniyi, PHYTOCHEMICAL AND ANTISICKLING ACTIVITIES OF TERMINALIA CATAPPA (COMBRETACEAE) LEAF EXTRACTS African Journal of Traditional, Complementary and Alternative Medicines. ,vol. 6, pp. 480- 481 ,(2009)
M.-Geneviève Dijoux-Franca, Diderot Noungoué Tchamo, Bruno Cherel, Max Cussac, Etienne Tsamo, Anne-M. Mariotte, New Dihydrophenanthrene and Phenyldihydroisocoumarin Constituents of Trema orientalis Journal of Natural Products. ,vol. 64, pp. 832- 835 ,(2001) , 10.1021/NP000275S
Brian Greenwood, Theonest Mutabingwa, Malaria in 2002 Nature. ,vol. 415, pp. 670- 672 ,(2002) , 10.1038/415670A
David A. Fidock, Philip J. Rosenthal, Simon L. Croft, Reto Brun, Solomon Nwaka, Antimalarial drug discovery: efficacy models for compound screening Nature Reviews Drug Discovery. ,vol. 3, pp. 509- 520 ,(2004) , 10.1038/NRD1416
Oyindamola Abiodun, Grace Gbotosho, Edith Ajaiyeoba, Tientcha Happi, Mofolusho Falade, Sergio Wittlin, Akintunde Sowunmi, Reto Brun, Ayoade Oduola, None, In vitro antiplasmodial activity and toxicity assessment of some plants from Nigerian ethnomedicine Pharmaceutical Biology. ,vol. 49, pp. 9- 14 ,(2011) , 10.3109/13880209.2010.490224
M.G.L Brandão, A.U Krettli, L.S.R Soares, C.G.C Nery, H.C Marinuzzi, Antimalarial activity of extracts and fractions from Bidens pilosa and other Bidens species (Asteraceae) correlated with the presence of acetylene and flavonoid compounds Journal of Ethnopharmacology. ,vol. 57, pp. 131- 138 ,(1997) , 10.1016/S0378-8741(97)00060-3
Kevin Marsh, Malaria disaster in Africa The Lancet. ,vol. 352, pp. 924- 924 ,(1998) , 10.1016/S0140-6736(05)61510-3
E. O. Adewoye, A. T. Salami, V. O. Taiwo, Anti-plasmodial and toxicological effects of methanolic bark extract of Chrysophyllum albidum in albino mice Journal of Physiology and Pathophysiology. ,vol. 1, pp. 1- 9 ,(2010) , 10.5897/JPAP.9000002