In vitro antiplasmodial activity and toxicity assessment of some plants from Nigerian ethnomedicine
作者： Oyindamola Abiodun , Grace Gbotosho , Edith Ajaiyeoba , Tientcha Happi , Mofolusho Falade
DOI: 10.3109/13880209.2010.490224
关键词:
摘要: Context: The emergence and spread of Plasmodium falciparum-resistant parasites to nearly all available antimalarial drugs pose a threat malaria control necessitates the need continue search for new effective affordable drugs. Ethnomedicine has been shown be potential source compounds or template synthesis novel molecules.Objective: antiplasmodial activity toxicity assessment 30 plant extracts from eight medicinal plants identified in Nigerian ethnomedicine treatment febrile illnesses were evaluated.Materials methods: In vitro was evaluated using falciparum NF54 (sensitive drugs) K1 (chloroquine/pyrimethamine resistant) strains [3H]-hypoxanthine incorporation assay. Toxicity determined against mammalian L6 cells Alamar blue assay.Results: ethyl acetate extract leaves Ocimum gratissimum Linn. (Labiatae) hexane st...
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