ELAM-1 is an adhesion molecule for skin-homing T cells
作者： Louis J. Picker , Takashi K. Kishimoto , C. Wayne Smith , R. Aaron Warnock , Eugene C. Butcher
DOI: 10.1038/349796A0
关键词:
摘要: ENDOTHELIAL cell leukocyte adhesion molecule-1 (ELAM-1) has been described as an inducible endothelial cell-adhesion molecule for neutrophils, and is believed to have a key role in the extravasation of these cells at sites acute inflammation1–3. Here we report that ELAM-1-transfected COS also bind unique skin-associated subset circulating memory T defined by expression cutaneous lymphocyte-associated antigen4,5. expressing this antigen least well neutrophils expressed ELAM-1, whereas other lymphocytes peripheral blood poorly, or not all. Immunohistological survey chronically inflamed tissue specimens revealed vascular ELAM-1 occurs preference noncutaneous sites. We conclude chronic inflammation, may function skin addressin, tissue-selective skin-homing lymphocytes.
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sci-hub.se 参考文章(23)
L. J. Picker, E. C. Butcher, L. S. Rott, S. A. Michie, A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites. American Journal of Pathology. ,vol. 136, pp. 1053- 1068 ,(1990)
F W Luscinskas, M A Gimbrone, A F Brock, M A Arnaout, Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium. Journal of Immunology. ,vol. 142, pp. 2257- 2263 ,(1989)
T A Springer, M W Makgoba, D Stephany, S O Sharrow, S Shaw, M E Sanders, H A Young, Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production. Journal of Immunology. ,vol. 140, pp. 1401- 1407 ,(1988)
D O Haskard, S M Wellicome, G S Panayi, M H Thornhill, C Pitzalis, J S Lanchbury, D S Thomas, A monoclonal antibody that detects a novel antigen on endothelial cells that is induced by tumor necrosis factor, IL-1, or lipopolysaccharide. Journal of Immunology. ,vol. 144, pp. 2558- 2565 ,(1990)
L. J. Picker, E. C. Butcher, L. W. M. M. Terstappen, P. R. Streeter, L. S. Rott, H. Stein, Differential expression of homing-associated adhesion molecules by T cell subsets in man. Journal of Immunology. ,vol. 145, pp. 3247- 3255 ,(1990)
Warren Chin, John B. Hay, A comparison of lymphocyte migration through intestinal lymph nodes, subcutaneous lymph nodes, and chronic inflammatory sites of sheep Gastroenterology. ,vol. 79, pp. 1231- 1242 ,(1980) , 10.1016/0016-5085(80)90918-X
Timothy A. Springer, Adhesion receptors of the immune system. Nature. ,vol. 346, pp. 425- 434 ,(1990) , 10.1038/346425A0
B. Seed, A. Aruffo, Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 84, pp. 3365- 3369 ,(1987) , 10.1073/PNAS.84.10.3365
Robert Sackstein, Vincent Falanga, J Wayne Streilein, Yee-Hon Chin, Lymphocyte adhesion to psoriatic dermal endothelium is mediated by a tissue-specific receptor/ligand interaction. Journal of Investigative Dermatology. ,vol. 91, pp. 423- 428 ,(1988) , 10.1111/1523-1747.EP12476441
R S Cotran, M A Gimbrone, M P Bevilacqua, D L Mendrick, J S Pober, Induction and detection of a human endothelial activation antigen in vivo. Journal of Experimental Medicine. ,vol. 164, pp. 661- 666 ,(1986) , 10.1084/JEM.164.2.661