Saccharomyces cerevisiae Sae2- and Tel1-dependent single-strand DNA formation at DNA break promotes microhomology-mediated end joining

作者: Kihoon Lee , Sang Eun Lee

DOI: 10.1534/GENETICS.107.076539

关键词:

摘要: … Our data support the role of Sae2 and Tel1 in MMEJ and … We found that deletion of SAE2 or TEL1 improved cell survival up to … We found that depletion of SAE2 or TEL1 reduced the …

参考文章(94)
Wolfram Siede, Graham C. Walker, Errol C. Friedberg, DNA Repair and Mutagenesis ,(2006)
Kum Kum Khanna, Stephen P. Jackson, DNA double-strand breaks: signaling, repair and the cancer connection. Nature Genetics. ,vol. 27, pp. 247- 254 ,(2001) , 10.1038/85798
Kelly M. Trujillo, Patrick Sung, DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex. Journal of Biological Chemistry. ,vol. 276, pp. 35458- 35464 ,(2001) , 10.1074/JBC.M105482200
Thomas E. Wilson, Ulf Grawunder, Michael R. Lieber, Yeast DNA ligase IV mediates non-homologous DNA end joining Nature. ,vol. 388, pp. 495- 498 ,(1997) , 10.1038/41365
Elizabeth A. Morgan, Lorraine S. Symington, Sylvie Moreau, Overlapping functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 nucleases in DNA metabolism. Genetics. ,vol. 159, pp. 1423- 1433 ,(2001) , 10.1093/GENETICS/159.4.1423
Sang Eun Lee, Debra A Bressan, John HJ Petrini, James E Haber, Complementation between N-terminal Saccharomyces cerevisiae mre11 alleles in DNA repair and telomere length maintenance DNA Repair. ,vol. 1, pp. 27- 40 ,(2002) , 10.1016/S1568-7864(01)00003-9
Lumir Krejci, Stephen Van Komen, Ying Li, Jana Villemain, Mothe Sreedhar Reddy, Hannah Klein, Thomas Ellenberger, Patrick Sung, DNA helicase Srs2 disrupts the Rad51 presynaptic filament Nature. ,vol. 423, pp. 305- 309 ,(2003) , 10.1038/NATURE01577